Also, the conversation will not end after each question. It is possible to do this without the perk though, but Lady Killer eliminates the possibility of a Speech check failure. In Fallout: New Vegas it is supplemented by Confirmed Bachelor perk.

Outside of combat, you'll sometimes have access to unique dialogue options when dealing with the opposite sex, similar to the Sex Appeal trait. In combat, you do +10% damage against female humans and non-feral ghouls.